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Development of Antibody?Oligonucleotide Complexes for Targeting Exosomal MicroRNA
http://hdl.handle.net/10069/40162
http://hdl.handle.net/10069/40162e88f8193-d0ff-47fe-84b9-e09e0166197e
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
Pharmaceutics12_545.pdf (7.7 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-08-07 | |||||
| タイトル | ||||||
| タイトル | Development of Antibody?Oligonucleotide Complexes for Targeting Exosomal MicroRNA | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Antibody | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Drug delivery system | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Exosome | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | MicroRNA | |||||
| キーワード | ||||||
| 主題Scheme | Other | |||||
| 主題 | Nucleic acid drug | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
Yamayoshi, Asako
× Yamayoshi, Asako× Oyama, Shota× Kishimoto, Yusuke× Konishi, Ryo× Yamamoto, Tsuyoshi× Kobori, Akio× Harada, Hiroshi× Ashihara, Eishi× Sugiyama, Hiroshi× Murakami, Akira |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | MicroRNAs in exosomes (exosomal miRNAs) are considered as significant targets for cancer therapy. Anti-miR oligonucleotides are often used for the functional inhibition of miRNAs; however, there are no studies regarding the regulation of exosomal miRNA functions. In this study, we attempted to develop a novel drug delivery system using anti-exosome antibody?anti-miR oligonucleotide complexes (ExomiR-Tracker) to hijack exosomes to carry anti-miR oligonucleotides inside exosome-recipient cells. We found that ExomiR-Tracker bound to the exosomes, and then the complexes were introduced into the recipient cells. We also found that anti-miR oligonucleotides introduced into the recipient cells can exhibit inhibitory effects on exosomal miRNA functions in vitro and in vivo. We believe that our strategy would be a promising one for targeting exosomal miRNAs. | |||||
| 書誌情報 |
Pharmaceutics 巻 12, 号 6, p. 545, 発行日 2020-06-12 |
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| 出版者 | ||||||
| 出版者 | MDPI | |||||
| EISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 19994923 | |||||
| DOI | ||||||
| 関連タイプ | isIdenticalTo | |||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/pharmaceutics12060545 | |||||
| 権利 | ||||||
| 権利情報 | c 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 引用 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Pharmaceutics, 12(6), art.no.545; 2020 | |||||
